Novel treatments for systemic amyloidosis
نویسندگان
چکیده
Amyloidosis is characterized by the deposition of protein fi brils with a β-sheeted structure. This structure is responsible for the insolubility of the protein fi brils, their resistance to proteolysis and binding affi nity of Congo red dye, and the green birefringence observed with polarized light. In systemic amyloidosis, deposition of amyloid fi brils in (vital) organ systems leads to organ dysfunction and, if untreated, eventually leads to death. A prerequisite for adequate treatment is a proper diagnostic and prognostic work-up [1,2].
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